Alzheimer's risk linked to B vitamins

B vitamins play a key role moderating the risk of Alzheimer's disease, research has shown.

A seven-year study from researchers at the Karolinska Institute in Sweden showed people with elevated vitamin B12 were at reduced risk of Alzheimer’s.

Researchers believe the study reinforces the link between B vitamins and the condition. The Alzheimer’s Research Trust called for a large-scale trial to conclusively prove the association.

Many previous studies had linked the amino acid homocysteine, which is associated with vitamin B12, to the development of cardio/cerebrovascular diseases.

To examine whether there was also a link with Alzheimer’s, researchers analysed blood samples of 271 Finnish people aged 65-79 without dementia.

Samples were tested for homocysteine and the active element of vitamin B12, holotranscobalamin.

Researchers saw that elevated homocysteine levels increased the risk of Alzheimer’s. But they also found a rise in holotranscobalamin levels reduced risk.

Researchers said further work may allow vitamin B12 to be used as a marker to identify patients at increased risk.

Professor Helga Refsum of the Alzheimer’s Research Trust said: ‘This study adds further evidence that low vitamin B12 status is associated with Alzheimer's, and it is probably the first to link the active component of the vitamin to the incidence of dementia.’
 
Rebecca Wood, chief executive of the Alzheimer’s Research Trust, said: ‘Discussion continues around how much promise B vitamins hold in protecting us from dementia, a debate that can only be put to bed by a comprehensive large scale trial.’

But she warned against patients ‘stocking the cupboard’ with vitamin B supplements, saying it was too early to be sure of the benefits.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

Rising medicines shortages drive up GP workload and risk for patients

Rising medicines shortages drive up GP workload and risk for patients

Growing medicines shortages have forced more than four in five GPs to prescribe second...

Medical examiners to scrutinise deaths in community settings

Medical examiners to scrutinise deaths in community settings

The MDU's Dr Kathryn Leask explains how the expansion of the medical examiner system...

GPs yet to receive thousands of pounds in QOF pay amid PCSE problems, says BMA

GPs yet to receive thousands of pounds in QOF pay amid PCSE problems, says BMA

Around 1,000 GP practices have yet to receive QOF payments potentially worth up to...

Vaccine gap leaves parts of England more exposed amid Delta variant surge

Vaccine gap leaves parts of England more exposed amid Delta variant surge

A far higher proportion of people have received both doses of COVID-19 vaccine in...

Bullying has continued in LMCs post-Romney review, GP whistleblower warns

Bullying has continued in LMCs post-Romney review, GP whistleblower warns

Bullying and sexism are continuing within local medical committees two years after...

UK COVID-19 vaccination programme tracker

UK COVID-19 vaccination programme tracker

GPs across the UK are playing a leading role in the largest-ever NHS vaccination...