Test your knowledge on myelofibrosis

Read the article on myelofibrosis then answer these three questions to check your understanding. You may want to document your answers and any learning points to save in your CPD folder along with the article.

Read our clinical feature on haematology

TEST YOUR KNOWLEDGE ON HAEMATOLOGY
QUESTION 1
What are the commonest symptoms and signs of myelofibrosis?
ANSWER
Severe, unexplained fatigue is the commonest symptom. Clinical examination reveals splenomegaly in almost all cases.
QUESTION 2
 How do you diagnose myelofibrosis?
ANSWER
Peripheral blood film reveals anaemia and a leucoerythroblastic picture in combination with teardrop-shaped red cells. Bone marrow examination shows the increased fibrosis which is confirmatory in the clinical setting.
QUESTION 3
What complications can a patient with myelofibrosis develop?
ANSWER
Extra-medullary haematopoiesis can develop in any organ and cause symptoms related to the specific site. Repeated transfusions to correct anaemia can cause iron overload. Marked splenomegaly can be a risk factor for splenic infarcts. Myelofibrosis can transform to acute leukaemia.

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