Study dismisses PPI cancer link

Long-term use of proton pump inhibitors (PPIs) does not appear to increase the risk of developing oesophageal cancer, UK research has found.

It has been suggested that long-term PPI use to reduce the discomfort of heartburn could increase the risk of developing Barrett's Oesophagus (BE), which can in turn develop into oesophageal adenocarcinoma.

Researchers from Leicester Royal Infirmary and Queen Mary, University of London looked at tissue samples from the oesophagus lining of 90 volunteers, each of whom were given high or low PPI dosages.

Overall, there was no difference in the rate of BE development nor change in levels of pre-cancerous cells in either group.

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