The study of 1,126 men over 50 showed that ED incidence was 93 cases per 1,000 person-years in users of NSAIDs, compared with 35 cases per 1,000 in those who did not take the painkillers.
The men were questioned about ED, illnesses and medication use at baseline and five years later. NSAIDs were reported by 146 men at the first assessment and 101 at the second.
Age, smoking, other medical indications and medications did not account for the effect.
J Urol 2006; 175: 1,812-6