Patients with advanced renal failure may benefit from treatment with an ACE inhibitor, Chinese research has found. In a trial of 224 patients with advanced renal failure, treatment with the ACE inhibitor benazepril was found to reduce the risk of severe renal disease, raised serum creatine levels or death by 43 per cent. The effect was independent of any effects on BP. An editorial on the findings suggested that ACE inhibitors should replace treatment with other anti-hypertensives if the results are confirmed by other studies and differences between Chinese and Western populations are shown to be transferrable. (N Engl J Med 2006; 354: 131-40, 189-91).
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