Although cardiovascular disease (CVD) is largely preventable, it causes over 40,000 people a year to die prematurely, the institute pointed out.
As part of its guidance on population-level interventions to prevent CVD, NICE said trans fats should be eliminated from food.
Such fats have been shown to increase the risk of heart disease and are classified as toxic by the WHO.
RCGP chairman Professor Steve Field said GPs were confronted with 'the harsh reality of CVD' on a daily basis.
'The recommendations in the new NICE guidance will be welcomed by GPs as they provide sensible ways in which individuals and society as a whole can make small changes that could lead to a big difference in reducing the risk of this life-threatening but largely preventable disease,' he said.
'We particularly welcome the onus placed on fast food and take away outlets to significantly reduce the amount of salt and trans fats in their food.'