Pulmonary fibrosis has genetic basis

Pulmonary fibrosis could be the result of a genetic error in patients with the condition, US researchers believe.

Dr Max Seibold and colleagues from the University of Colorado, studied genetic mutations in 492 patients with idiopathic pulmonary fibrosis.

They looked at expression of the MUC5B gene which has been linked to pulmonary fibrosis in previous studies.

Patients were compared with 322 controls. Those with a particular genetic mutation in the MUC5B gene were nine times more likely to have idiopathic pulmonary fibrosis than those who did not have the mutation.

Writing in the New England Journal of Medicine, the researchers said: 'A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis. Our findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis.'

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Before commenting please read our rules for commenting on articles.

If you see a comment you find offensive, you can flag it as inappropriate. In the top right-hand corner of an individual comment, you will see 'flag as inappropriate'. Clicking this prompts us to review the comment. For further information see our rules for commenting on articles.

comments powered by Disqus