A committee of representatives from 31 London PCTs and Surrey PCT endorsed Lord Ara Darzi's Healthcare for London plans, ending a four month consultation.
Richard Sumray, chairman of the Joint Committee of PCTs (JCPCT), said: 'This is the start of the journey, and the NHS as a whole will need to be bold and make difficult decisions, in order to deliver the kind of services that Londoners have told us they want.'
Just 51 per cent of responses to the consultation were in favour of polyclinics. NHS London will now develop 10 polyclinic pilots in the capital, with the aim of having up to 150 within a decade.
At last week's annual LMCs conference in London, there was fierce opposition to Lord Darzi and his plans. GPC chairman Dr Laurence Buckman promised 'a never-ending fight' against polyclinics.