Homocysteine link to CVD risk in psoriasis

High levels of homocysteine could be responsible for the increased cardiovascular risk seen in psoriasis patients, according to Irish research presented at the British Association of Dermatologists' meeting in Manchester last week.

The researchers compared serum levels of folate, homocysteine, lipids and glucose in 20 patients with type-1 psoriasis with levels in 20 controls.

They measured the patients' psoriasis area and severity, as well as BMI and BP. They found psoriasis patients were five times more likely to have raised homocysteine levels than controls.

More than 27 per cent of patients with psoriasis had homocysteine levels greater than 12mu ml/l compared to just 5 per cent of controls.

The patients with psoriasis were also more likely to be overweight, with 17 patients having a BMI over 25 compared to just five controls.

Researchers concluded that the high prevalence of hyperhomocysteineaemia in psoriasis patients could play a role in their increased cardiovascular risk.

British Journal of Dermatology 2006; 155 (suppl.1): 1-9

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