High statin dose cuts risks in CHD

CHD patients should be kept on a high dose of statins by GPs to reduce the risk of heart failure, according to US research.

The subgroup analysis of 10,000 men and women, aged between 35 and 75, found that patients with CHD, but without a history of heart failure, who took an 80mg dose of atorvastatin benefited from a 26 per cent reduced risk of hospitalisation due to heart failure, compared with patients who were taking the 10mg dose.

In CHD patients, the benefit of intensive statin treatment was found to be greater with the risk of heart failure cut by 41 per cent.   

Professor Mike Kirby, Hertfordshire GP and member of the Primary Care Cardiovascular Society, said that high-risk patients should be on a higher dose of statin in line with the JBS2 guidelines, which state that the dose of statin should be titrated up to achieve the total cholesterol and LDL cholesterol targets.

There are, however, side-effects associated with higher statin doses such as muscular aches and pains, he added.

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