People can walk through the inflated structure to find out more about how the digestive system works.
The DoH recently launched its Be Clear On Cancer campaign, backed by £8.5m.
All patients in England aged 60-69 are invited for screening every two years, but in parts of Sheffield just 30% take part.
Dr Marion Sloan, a partner in the Sloan Medical Practice, part of Central Sheffield GP Consortium, said: 'We want everyone to be aware of why it’s important that all those who are eligible take the test. The message is very clear - this test could save your life.'
The model will be inflated in the car parks of Sheffield practices throughout September.