Enzyme may predict coronary artery calcification

Elevated levels of serum alkaline phosphatase in hemodialysis (HD) patients may predict coronary artery calcification (CAC), which is associated with cardiovascular and mortality in this population.

Originally published on Renal and Urology News - World Review For Urologists and Nephrologists.

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In a study of 137 HD patients, Ronney Shantouf, MD, of the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center in Torrance, Californioa, and colleagues found that a calcium artery calcification score (CACS) of 400 or more is five times more likely to occur among patients in the highest tertile of serum alkaline phosphatase (120 mg/dL or higher) compared with those in the second tertile (reference; 85-119 mg/dL), after adjusting for age, gender, presence of diabetes mellitus, Charlson comorbidity score, dialysis vintage, interleukin-6, and serum glutamic oxaloacetic transaminase. The researchers observed no association between the first quartile of serum alkaline phosphatase and the likelihood of a CACS of 400 or more.

The mean CACS for patients with a serum alkaline phosphatase level of 120 mg/dL or higher was about twice that of subjects with lower levels.

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