The warning comes as the first polypill trial found it cut heart disease risk by a quarter.
The trial, of 2,053 people aged 45-80 with no cardiovascular disease, found it cut BP, heart rate and LDL cholesterol.
The polypill, which contains hydrocholorothiazide, atenolol, ramipril, simvastatin and aspirin, was tolerable and there was no evidence that tolerability fell as the number of active components per pill increased.
But North Yorkshire GP Dr Terry McCormack, former Primary Care Cardiovascular Society chairman, said components of polypills may harm some patients. 'Drugs need to be tailored to the needs of the individual patient,' he added.
- Lancet Online 2009
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